Isosorbide Dinitrate Tab 20mg, 100ct Bottle

Per Order QTY



What is Isosorbide Dinitrate and how is it used?

Isosorbide Dinitrate (isosorbide dinitrate) is a nitrate indicated for the prevention of angina due to coronary artery disease and congestive heart failure. Isosorbide Dinitrate is available in generic form.

What are side effects of Isosorbide Dinitrate?

Common side effects of Isosorbide Dinitrate include:

  • headache,
  • weakness,
  • mild dizziness, and
  • skin changes such as redness, tingling, or warmth.

Serious side effects of Isosorbide Dinitrate include:

  • heart rate changes,
  • increased chest pain (angina),
  • fainting or near-fainting,
  • nausea and vomiting,
  • sweating,
  • pale skin,
  • blurry vision, and
  • shortness of breath.


Isosorbide Dinitrate (isosorbide dinitrate) Titradose tablets are indicated for the prevention of angina pectoris due to coronary artery disease. The onset of action of immediate-release oral isosorbide dinitrate is not sufficiently rapid for this product to be useful in aborting an acute anginal episode.


As noted under CLINICAL PHARMACOLOGY, multiple-dose studies with ISDN and other nitrates have shown that maintenance of continuous 24-hour plasma levels results in refractory tolerance. Every dosing regimen for Isosorbide Dinitrate Titradose tablets must provide a daily dose-free interval to minimize the development of this tolerance. With immediate-release ISDN, it appears that one daily dose-free interval must be at least 14 hours long.

As also noted under CLINICAL PHARMACOLOGY, the effects of the second and later doses have been smaller and shorter-lasting than the effects of the first.

Large controlled studies with other nitrates suggest that no dosing regimen with Isosorbide Dinitrate Titradose tablets should be expected to provide more than about 12 hours of continuous anti-anginal efficacy per day.

As with all titratable drugs, it is important to administer the minimum dose which produces the desired clinical effect. The usual starting dose of Isosorbide Dinitrate Titradose is 5 mg to 20 mg, two or three times daily. For maintenance therapy, 10 mg to 40 mg, two or three times daily is recommended. Some patients may require higher doses. A daily dose-free interval of at least 14 hours is advisable to minimize tolerance. The optimal interval will vary with the individual patient, dose and regimen.

Store at controlled room temperature, 25°C (77°F); excursions permitted to 15° to 30° (59° to 86°F) [see USP Controlled Room Temperature].

Protect from light.

Keep bottles tightly closed.

Dispense in a light-resistant, tight container.

Keep out of reach of children.